Southern Comfort Catfish & Cornbread Casserole

🌍 Cuisine: Southern American
🏷️ Category: Main Course
⏱️ Prep: 25 minutes
🍳 Cook: 35-40 minutes
👥 Serves: 6 servings

📝 About This Recipe

This soul-warming seafood bake reimagines the classic flavors of the Mississippi Delta in a single, bubbling dish. Flaky, farm-raised catfish fillets are nestled in a creamy, savory base of sweet corn and pimientos, then topped with a golden, buttery cornbread crust. It’s a sophisticated yet rustic approach to Southern comfort food that transforms simple ingredients into a festive centerpiece.

🥗 Ingredients

The Seafood Base

  • 1.5 pounds Catfish fillets (cut into 1-inch bite-sized chunks)
  • 1 teaspoon Old Bay Seasoning
  • 1 tablespoon Lemon juice (freshly squeezed)

The Creamy Filling

  • 3 tablespoons Unsalted butter
  • 1 medium Yellow onion (finely diced)
  • 2 pieces Celery stalks (thinly sliced)
  • 1/2 cup Red bell pepper (diced)
  • 3 Garlic cloves (minced)
  • 10.5 ounces Cream of celery soup (one standard can)
  • 1/2 cup Sour cream (full fat preferred)
  • 1 cup Whole kernel corn (frozen or canned and drained)
  • 2 tablespoons Diced pimientos (drained)
  • 1/2 teaspoon Dried thyme

The Cornbread Topping

  • 8.5 ounces Corn muffin mix (one box, like Jiffy)
  • 1 large Egg (beaten)
  • 1/3 cup Whole milk
  • 1 cup Sharp cheddar cheese (freshly shredded)
  • 2 tablespoons Fresh parsley (chopped for garnish)

👨‍🍳 Instructions

  1. 1

    Preheat your oven to 375°F (190°C). Grease a 9x13 inch baking dish or a 2-quart casserole dish with butter or non-stick spray.

  2. 2

    Pat the catfish chunks dry with paper towels. In a medium bowl, toss the fish with lemon juice and Old Bay seasoning. Set aside to marinate briefly while you prep the sauce.

  3. 3

    In a large skillet over medium heat, melt the 3 tablespoons of butter. Add the onion, celery, and red bell pepper.

  4. 4

    Sauté the vegetables for 5-7 minutes until they are soft and the onions are translucent. Add the minced garlic and cook for another 60 seconds until fragrant.

  5. 5

    Stir in the cream of celery soup, sour cream, corn, pimientos, and dried thyme. Heat through until the mixture begins to simmer gently.

  6. 6

    Taste the sauce and add salt or black pepper if desired, keeping in mind the seasoning on the fish and the salt in the soup.

  7. 7

    Carefully fold the seasoned catfish chunks into the creamy vegetable mixture. Pour the entire mixture into the prepared baking dish, spreading it into an even layer.

  8. 8

    In a separate mixing bowl, combine the corn muffin mix, egg, and milk. Stir until just combined (a few lumps are okay).

  9. 9

    Fold half of the shredded cheddar cheese into the cornbread batter.

  10. 10

    Drop spoonfuls of the cornbread batter over the top of the catfish mixture. Use a spatula to spread it gently, though it doesn't need to cover every single inch—a few gaps allow steam to escape.

  11. 11

    Place the dish in the center of the oven and bake for 30 minutes.

  12. 12

    Remove the dish briefly and sprinkle the remaining cheddar cheese over the top. Return to the oven for another 5-10 minutes, or until the cornbread is golden brown and a toothpick inserted into the topping comes out clean.

  13. 13

    Let the casserole rest for 5-10 minutes before serving. This allows the sauce to thicken slightly. Garnish with fresh parsley and serve warm.

💡 Chef's Tips

Always pat your catfish dry before seasoning to ensure the spices stick and the fish doesn't release too much water into the sauce. If you prefer a spicier kick, add a teaspoon of hot sauce or a pinch of cayenne pepper to the creamy filling. Avoid over-mixing the cornbread batter; mixing until 'just combined' ensures a light, fluffy topping rather than a dense one. For a crunchier topping, you can sprinkle a handful of crushed saltine crackers or Ritz crackers over the cheese during the last 5 minutes of baking.

🍽️ Serving Suggestions

Serve alongside a crisp green salad with a sharp vinaigrette to balance the richness of the cream sauce. Pairs beautifully with steamed green beans or sautéed collard greens for a full Southern spread. A glass of chilled Sweet Tea or a crisp Sauvignon Blanc cuts through the buttery flavors perfectly. Offer extra lemon wedges on the side for those who like a bright, citrusy finish to their seafood.